WHO Warns On The Use Of Remdesivir As Covid-19 Treatment

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Remdesivir, which previously failed in trials against Ebola, is being touted as helping to improve outcomes against the COVID-19

PARIS – The United States, the European Union and other countries have granted temporary approval for the use of remdesivir after initial research showed it may shorten recovery time in some coronavirus patients.

President Donald Trump was treated with remdesivir among other medicines after he tested positive for COVID-19 in October.

Friday’s WHO recommendation was based on four international randomised trials among more than 7,000 patients hospitalised with the virus.

Publishing updated treatment guidance in the BMJ medical journal, the panel acknowledged that their recommendation does not mean that remdesivir has no benefit for patients.

But based on the latest figures, costs and delivery methods, it advised “against administering remdesivir in addition to usual care for the treatment of patients hospitalised with COVID-19, regardless of disease severity”.

The panel recommended that remdesivir trials continued, however, adding that their advice didn’t constitute proof that the treatment couldn’t work in COVID-19 cases.

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“That’s why it’s a conditional recommendation. (There may) still be potential small benefit, maybe in a subgroup (of patients),” Janet Diaz, the WHO’s head of clinical care, told reporters on Friday.

“Is there a subgroup that may benefit more, such severe patients versus critical patients”?

Manufacturer Gilead said that remdesivir was recognised as COVID-19 treatment by several official health agencies, including the US National Institutes of Health and Infectious Diseases of America, based on “robust data from several randomised control trials”.

“We regret that the WHO recommendation do not take this data into account even as the number of new cases globally is increasing considerably,” it said.

The US pharma giant said last month that the drug had boosted 2020 third-quarter sales by almost $900 million.

Initially developed as a treatment for the Ebola virus, remdesivir was found in one study published in May to reduce the length of hospital stays for COVID-19 sufferers from 15 to 11 days on average.

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A subsequent WHO pre-print, however, found the drug “appeared to have little or no effect” on mortality or length of hospitalisation among more than 11,000 hospitalised patients across 30 countries.

Peter Horby, professor of Emerging Infectious Diseases and Global Health at Oxford’s Nuffield Department of Medicine, said the WHO’s recommendation would require a rethink in how hospitalised COVID-19 cases are treated.

“Remdesivir is an expensive drug that must be given intravenously for five to ten days, so this recommendation will save money and other healthcare resources,” he said.

EWN

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